Mayo Clinic Second Opinion Cost & Process Guide 2025

Mayo Clinic is the largest not-for-profit medical group, also involved in research that “turns into earlier diagnoses and new cures.” They have a group of experts that work together to solve the most challenging needs of patients.

They also offer quality care with top-ranked specialties.

In the list of patient services they offer, second opinion is one of the top services that has helped improve countless lives. If you are looking for a second opinion from Mayo clinic, you are in the right place.

Read on to find out all the steps about how to apply for Mayo Clinic second opinion, its cost and the complete guide.

Why Consider a Mayo Clinic Second Opinion?

• Expert experience

• Access to multiple specialists

• Better health outcomes

Mayo Clinic offers second opinion where experts re-evaluate your medical reports as if you are already at the clinic for a physical check-up. This service from the comfort of your home helps you get the best of both worlds - get an expert second opinion while never bearing the hassle of travel.

Second opinion at Mayo Clinic brings you expert experience, especially from those with high volume experience. You benefit from this by getting better treatment guidance. You also get access to multiple specialists from different fields who can review the case together.

A second opinion that comes from such experts is comprehensive and helps align the patient’s treatment to the best outcome. The initial diagnosis can either be confirmed or corrected with the help of this second opinion.

This prevents harmful treatments that could negatively affect the patient’s health. This brings a peace of mind that only comes with the right treatment plan.

How Do You Get a Second Opinion from Mayo Clinic?

Wondering how do I get a second opinion from Mayo Clinic? There are three simple steps that can help you get a Mayo Clinic virtual second opinion:

• Contact Mayo Clinic

• Discuss Your Case (after you submit the relevant documents)

• Plan Your Visit

Follow these steps to book a second opinion easily:

Step 1: Contact Mayo Clinic

• The first step is navigating to the official Mayo Clinic website and finding the “Request an Appointment” tab. You will see the following page:

• You can get your second opinion from the first option or scroll down to find a list of contact numbers that help you get in touch with the appointment coordinators at respective clinic locations.

• When booking a second opinion from the first option (or any other if applicable), you can set a time during which the appointment coordinator will reach out to you.

• If you are in the US or outside, you can find respective sections to contact the appointment coordinator.

• From here, you can simply book an appointment suitable to you - through either methods.

• When applying online, you can get an estimate of the cost for second opinion directly at the end, this can help you know its cost, too.

Step 2: Discuss Your Case

• Once you get in touch with a appointment coordinator, they will guide you through the process which involves submitting your reports and other relevant information.

• Wait for the assessment as the Mayo Clinic team will review your case and determine if it can accepted for a second opinion or needs deeper attention through care.

Step 3: Plan Your Visit

• Once your case is reviewed by the Mayo Clinic, they will inform if a virtual visit will suffice or if you need a visit to the clinic.

• Once decided, plan your visit accordingly if needed.

• If a virtual consultation or a treatment plan will suffice, you will receive a consultation or an appointment with a Mayo Clinic physician.

Cost of Second Opinion with Mayo Clinic

The Mayo Clinic second opinion cost usually ranges between $500 to $2,500. There are different factors that affect the cost which are as below:

• Virtual second opinion: For US residents, the fee is usually between $700 to $2,500 with a comprehensive written second opinion from a Mayo Clinic specialist. This depends on the specialty and complexity of the condition.

• International patients: The charges for this group of people are on the higher end due to the logistics and coordination. This can cost $2,000 or above depending on the condition.

• Simple e-consultation: Some clinics affilitaed with Mayo Clinic can charge up to $500-$700 for reviewing your case and providing brief recommendation.

• In-person evaluation: The charges depend on the length of visit, department, labs and scans and insurance coverage. It can go even higher if the consultations lead to additional tests or follow-up. It starts from $1,000 and goes up.

Once you choose from the list of 20 clinics, you can get the specic cost for your second opinion depending on the service type as below:

What to Expect in Your Second Opinion from Mayo Clinic

A second opinion at Mayo Clinic can help you get in touch with experts from the top institutions. You can expect the following from your second opinion appointment at Mayo Clinic:

• Comprehensive review of your medical records. The team at Mayo Clinic meticulously reviews the shared documents. They review your medical records to ensure nothing is overlooked.

• Multidisciplinary team looks into your case which provides a holistic view of the condition. Depending on this, your case can get expert look which is important for complex cases.

• Personalized treatment plans tailored to your specific needs and goals. This includes any treeatment options that you may need or options that were previously not considered.

• Shared decision-making, clear explanations of your condition and treatment can be received, that helps understand your choices. This encourages active participation in your decision-making.

• Focus on your well-being, the ultimate goal with Mayo Clinic is to help you gain confidence and independence in decision-making.

• Confirmed diagnosis or a course-correction where needed. A second opinion helps provide confidence in the treatment path you will take. It can also help you identify the refined or new diagnoses

Second Opinion from Mayo Clinic for International Patients

International patients can benefit from second opinion with Mayo Clinic by getting expert consultation without travelling. Just share your medical documents and you can take advantage of time-zone flexibility and document translation with Yapita Health.

Schedule your second opinion with Mayo Clinic with Yapita Health, with coordinators supporting you 24x7.