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CAR-T cell Therapy Cost in India

55000 $

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45000 $

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Effective and Affordable CAR-T cell Therapy in India

What Is CAR T-cell Therapy?

An innovative approach to treating cancer, CAR-T cell therapy is a type of immunotherapy that genetically modifies the T-cells in patients. A T-cell is a type of white blood cell that helps fight off infections and threats.

This therapy is a cell-based gene therapy type that involves taking T cells from a patient’s blood. After which they modify it in the lab and infuse it back into their body.

This helps the body fight cancer better with the help of CAR (chimeric antigen receptors) that attach to the cancer cells and improve attack.

Thus, what the therapy does is reprogram the patient’s T cells to target cancer cells more aggressively. India is gaining popularity in this treatment due to the success rates, in particular in relapsed or refractory leukemia and lymphoma.

Types of CAR-T cell Therapy along with Cost Comparison in different Countries

CAR T-cell Therapy Cost in India

Now that you know about this therapy, it is time you know the CAR T-cell therapy cost in India.

CAR T-cell therapy can cost anywhere around $45,000 to $85,000, which is substantially less than its cost outside, which can reach $350,300 and above.

The treatment cost can also vary depending on the origin of the therapy. For example:

Indigenous CAR-T therapy, or NexCAR19, costs around ₹40 lakhs and above ($45,000 to $85,000).
Global CAR-T therapy costs anywhere between $400,000 and $500,000, in addition to hospitalization costs.
Imported CAR-T therapy can cost around ₹3-4 crore ($350,300 and above).
Var-cel (from Immuneel): This is an affordable option that costs around $55,000-$65,000 and is a licensed treatment from Barcelona.

Let’s look at the cost of this treatment globally, picking the top destinations offering it.

CAR T-cell therapy cost in India vs. Other Countries

Destination	Cost ($)
India	$45,000 to $85,000
US	$400,000 - $1 million (higher including hospital fees, etc.)
Turkey	$100,000 to $300,000
Canada	$390,000 to $550,000
Singapore	$375,000 to $475,000
Germany	$328,330 to $383,052

Why is CAR-T cell cost so low in India?

As evident from the comparison above, India is the most affordable destination for CAR-T cell therapy. Offering a sophisticated treatment at one-tenth of the cost in the US, here's why the cost are so low:

Indigenous development of the therapy like the NexCAR19, allows the cost to be low as there is low/no reliance on expensive imported products.
Local manufacturing of the CAR-T product at facilities in India allows control on the cost, thereby cutting down the package price.

Facilities in India like Apollo Hospitals (Mumbai, Chennai) provide the best results due to the presence of experienced professionals, high standards of care and well-equipped facility.

Also Read: Best Hospitals in India for CAR-T Cell Therapy

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Factors Affecting the Cost of CAR T-cell Therapy

As you may notice, the cost of this treatment is comparatively low in India. However, it is still up there on the higher side of treatment costs. Let’s have a look at the different factors that affect its cost:

Development and manufacturing cost: One of the most significant contributors to the cost of several novel treatments. Initial development and manufacturing include several expensive processes such as cell culturing and genetic modification. All of which require significant expertise and precision for successful results.
Clinical trial and regulatory costs: CAR T-cell therapies undergo rigorous clinical trials that ensure efficacy and stability. Regulatory compliance and associated costs contribute to the overall expense, shooting up their costs in the market.
Supply chain logistics: Logistical complexities and costs involved in transporting the patient cells to and from the lab after modification to the treatment center add to the cost.
Hospital costs: Another inevitable factor that adds to the overall treatment costs. Hospitals can bill a specific fee for administering the therapy, which includes the doctor’s and team’s fees.
Patient-specific costs: The overall costs vary based on the patient’s health and the necessary dosage.

Understanding these factors is necessary to overcome the complexities of CAR T-cell therapy costs in India.

Pre- and Post Medical Tests for CAR T-cell Therapy

Before the actual therapy, there are a few tests that you may have to undergo to ensure a smooth process:

Pre-CAR-T Therapy tests:

Blood tests for the blood counts, infection tests, and kidney or liver function tests that help assess the organ function.
Imaging scans: CT, PET, and MRI scans to assess the cancer’s extent and check for any spread. ECG, chest x-rays, and bone marrow aspiration are also conducted.
Other tests: Pulmonary function tests, neurological evaluation, and dental examination, along with baseline cognitive function tests for establishing baseline cognitive function.

Post-CAR-T therapy tests:

Observing vital signs for side effects of the therapy such as cytokine release syndrome and ICANS.
Monitoring the blood cell levels, kidney and liver function, and inflammatory markers through blood tests.
MRI, PET, and CT to monitor the recurrence of the cancer.
Neurological and cognitive function assessment for any cognitive changes.
Circulating tumor DNA (ctDNA) measurement: This helps monitor cancer recurrence.

These were all the necessary tests that you would have to undergo before and after the therapy.

Recovery

Now that your CAR-T therapy is successfully complete, it’s time to prolong the success. The recovery is crucial for the longevity of such a therapy - this is when you must follow the complete instructions of your doctor.

The recovery includes:

Staying at the hospital for typically 7-10 days, or maybe longer depending on your individual situation.
Close monitoring by your medical team for potential side effects, especially in the initial few weeks.
Restricted driving due to the possible neurological complications.
In addition, you’ll need to have a caregiver by your side 24/7 for the first month after discharge. This will help with proper monitoring and support.
Maintain follow-up appointments with your team to ensure proper monitoring
Gradually resume everyday activities with a steady rise in energy and stamina levels as before.
Maintain a healthy diet rich in nutrients and proteins that supports your recovery.

Recovery is unique for everyone, so be careful not to worry about the timeline and severity of the side effects. Keep open communication with your doctor and medical team even during recovery.

Related Pages of CAR-T Cell Therapy

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CAR-T cell Therapy Cost in India

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CAR-T cell Therapy with Yapita Health

FAQs Related to CAR-T Cell Therapy

Is CAR T Cell Therapy safe for elderly patients?

Yes, CAR T Cell Therapy can be safe for elderly patients, but individual health status must be considered. Older adults may have different responses to treatment, so a thorough evaluation by a healthcare professional is necessary.

Is CAR T Cell Therapy effective for pediatric patients?

Yes, CAR T Cell Therapy has shown promising results in pediatric patients, particularly for certain types of leukemia and lymphoma. The treatment is tailored to the child’s specific needs.

What are the common side effects of CAR T Cell Therapy?

Common side effects of CAR T Cell Therapy include fever, fatigue, nausea, and flu-like symptoms. However, they are temporary.

Is there a risk of infection after CAR T Cell Therapy?

Yes, there is a risk of infection after CAR T Cell Therapy due to the impact on the immune system. It’s crucial to follow hygiene practices and report any signs of infection, such as fever or chills.

How does CAR T Cell Therapy compare to traditional chemotherapy?

CAR T Cell Therapy is a more targeted approach compared to traditional chemotherapy, which affects both cancerous and healthy cells. This targeted nature often results in fewer side effects and improved outcomes for patients, specially for those with blood cancers.